Although this information will not take the place of a consultation with your physician, it should answer some of the questions you may have about treatments with Hylaform® (hylan B gel). This information may also help you and your physician decide whether Hylaform is right for you.

What causes wrinkles?
What is hyaluronic acid?
What is Hylaform?
What are dermal fillers?
What is Hylaform used for?
How does Hylaform work?
Is a pre-treatment skin test required?
Do the injections hurt?
Is the product safe?
Can anyone be treated with Hylaform?
Do I need to take time off to recuperate?
What areas can be treated with Hylaform?
How often will I require treatment?
Without touch-up injections, how will my skin look?
How are Hylaform treatments different from Botox® Cosmetic (Botulinum Toxin Type A)?
How are Hylaform treatments different from collagen treatments?
Can I get treatment with more than one filler?
Who can inject Hylaform?
How long does the procedure take? Can I have more than one area treated at the same time?
How do I know if a dermal filler is what I need?
How much do the treatments cost?
What should I find out before I have any type of medical cosmetic treatment?

What causes wrinkles?
The way your skin looks is directly related to the way your skin is supported. Wrinkles form when the natural collagen and hyaluronic acid in your skin diminish during the course of aging. Other factors that cause wrinkles include exposure to the sun, disease, injury, heredity and lifestyle. Collagen provides skin structure while hyaluronic acid provides volume to your skin.
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What is hyaluronic acid?
Hyaluronic acid is a natural sugar. It is found in the human body in the skin, cartilage, joints and the eyes.

In skin tissue, hyaluronic acid fills the space between collagen and elastin fibers. The role of hyaluronic acid in skin is to deliver nutrients, to hydrate the skin by holding in water and to act as a cushioning agent.
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What is Hylaform?
Hylaform is a dermal filler made of chemically modified hyaluronic acid. Hyaluronic acid is a natural sugar found in the fluids surrounding cells and tissues. It is chemically, physically and biologically similar in the tissues of all species. Hylaform is made from highly purified natural hyaluronic acid that is gradually absorbed by your body through natural mechanisms.
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What are dermal fillers?
Dermal fillers are substances that are injected just below the surface of the skin temporarily adding volume and/or structure, thereby filling lines, wrinkles and folds from the inside out. Dermal fillers can temporarily restore a smoother appearance.
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What is Hylaform used for?

Hylaform is injected into skin tissue for correction of moderate to severe facial wrinkles and folds such as nasolabial folds, commonly known as smile lines.
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How does Hylaform work?
Hylaform is injected just beneath the skin's surface temporarily adding volume to the layers of the skin that have deteriorated due to age and other factors. Hylaform, when injected, is used to raise depressions in the skin, providing temporary correction of wrinkles and folds.
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Is a pre-treatment skin test required?
No. You can receive Hylaform the same day as your initial consultation or office visit.
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Do the injections hurt?
In general, injections may cause some discomfort. Hylaform is injected directly into the skin using a fine needle to reduce injection discomfort. Physicians may choose to anesthetize or numb the treatment area to further minimize discomfort.
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Is the product safe?
Yes, for most people. The primary ingredient in Hylaform is hyaluronic acid, which is a component of skin. Hylaform has undergone extensive testing including scientific clinical trials to establish its safety and effectiveness. Hylaform was approved in April 2004 for injection into the skin for correction of moderate to severe facial wrinkles and folds (such as smile lines) by the U.S. Food and Drug Administration (FDA).
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Can anyone be treated with Hylaform?
Your physician will ask about your medical history,including allergies, to determine if you are an appropriate candidate for treatment.
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Do I need to take time off to recuperate?
Hylaform is a simple office procedure. Most patients feel comfortable resuming their normal activities immediately following treatment. Temporary puffiness of the treated areas, however, should be expected. As with any injection, you may also notice temporary redness, slight bruising and tenderness around the treatment sites. You are free to eat, drink, or wear makeup or sunblock shortly after treatment.
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What areas can be treated with Hylaform?
The most common areas treated are the smile lines around your nose and mouth, marionette lines at the corners of your mouth, frown lines between the eyes and fine lines above the mouth.
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How often will I require treatment?
To maintain optimal correction, touch-up injections are usually needed two or three times a year. Everyone's skin is different. That is why the timing of any additional treatment varies from person to person. Over time, Hylaform will be absorbed by your body, which is why you may want ongoing treatments. If you choose not to continue with your treatment, any remaining Hylaform is simply absorbed by your body over time and your skin gradually returns to its natural shape. Your physician can work with you to develop a treatment plan that is right for you.
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Without touch-up injections, how will my skin look?
Correction will reduce gradually until your skin looks like it did before treatment with Hylaform. Touch-up injections will help you maintain correction of the skin surface.
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How are Hylaform treatments different from Botox® Cosmetic (Botulinum Toxin Type A)?
Botulinum Toxin Type A is a protein that is injected into muscles to relax them, smoothing lines and wrinkles caused by repeated facial movements. In contrast, Hylaform is a dermal filler that is injected just below a wrinkle in order to "fill" it in, smoothing the surface of the skin.
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How are Hylaform treatments different from collagen treatments?
Hylaform temporarily adds volume to your skin by mimicking the hydrating effects of your skin's natural hyaluronic acid. Treatment with CosmoDerm® and CosmoPlast® (and bovine collagen) replenish your skin's lost collagen, restoring skin structure.
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Can I get treatment with more than one filler?
Although the safety and effectiveness of combination use has not been clinically evaluated, there is an emerging trend to use collagen and hyaluronic acid-based fillers in combination to temporarily replace lost structure and volume, smoothing away unwanted lines and wrinkles.
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Who can inject Hylaform?
Hylaform can be injected by a physician, such as a dermatologist or plastic surgeon or a qualified health care professional, such as a registered nurse or physician assistant.
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How long does the procedure take?
Treatment and recovery with Hylaform usually takes less than one hour.
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Can I have more than one area treated at the same time?
Yes, more than one area can safely be injected at the same time.
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How do I know if a dermal filler is what I need?
To help determine if a dermal filler is right for you, perform a simple stretch test. Pull your skin tight on either side of the wrinkle you want to test, this will allow you to assess the potential for optimal treatment capability. If the line/wrinkle goes away when the skin is pulled tight, then full correction may be achieved. Keep in mind that if you can still see a line when you pull the skin, your physician will be able to smooth the area and fill in the wrinkle, but you may still see the line.
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How much do the treatments cost?
Pricing varies depending on the number and types of areas being treated, the amount of filler material required to achieve the desired results and the physician administering the treatment. Typically treatments are priced competitively with other injectable wrinkle correction procedures.
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What should I find out before I have any type of medical cosmetic treatment?

• Is the product approved by the FDA?
• Who is performing the treatment? Do they have the proper training/credentials?
• When do you want to see results?
• Where are your problem areas?
• Make sure your doctor reviews all safety information provided by the manufacturer.

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